Estrogen receptor signal in regulation of B cell activation during diverse immune responses

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• 作者：Josaine Asaba^a ; Mausumi Bandyopadhyay^b ; Mark Kindy^c ; Subhajit Dasgupta^d ; ^e ; ^{sdasgupta@mail.sjsm.org" class="auth_mail" title="E-mail the corresponding author} ; ^{subhajitdasgupta@outlook.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Estrogen receptor ; B cell ; Immunoglobulin ; Bone marrow ; Class switch
• 刊名：International Journal of Biochemistry and Cell Biology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：68
• 期：Complete
• 页码：42-47
• 全文大小：913 K

文摘

The role of signalling through oestrogen receptors (ERs) in the regulation of B cell activation is an area of growing importance not only in terms protective immunity but also in the determination of the mechanisms of the onset of autoimmune disorders and cancers. The mode of signalling action of this single chain nuclear receptor protein molecule depends on its ability to bind to the promoters of Pax5, HOXC4 and apolipoprotein B RNA-editing enzyme activation-induced cytidine deaminase (AID) genes. ER-mediated transcriptional regulation induces class switch recombination of the immunoglobulin heavy chain variable (V_H) to D_H-J_H genes and somatic hypermutation in developing B cells. The mode of action of ER is associated with BCR-signal pathways that involve the regulator proteins BAFF and APRIL. Additionally, the plasma membrane-bound G protein-coupled oestrogen receptor-1 (GEPR1) directs diverse cell signalling events in B cells that involve the MAPK pathways. These signals are immensely important during progenitor and precursor B cell activation. We have focused our goals on the medicinal aspects of ER-signalling mechanisms and their effects on polyclonal B cell activation.