The low molecular weight fraction of commercial human serum albumin induces acetylation of α-tubulin and reduces transcytosis in retinal endothelial cells

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The low molecular weight fraction of commercial human serum albumin induces acetylation of α-tubulin and reduces transcytosis in retinal endothelial cells

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作者：Gregory W. Thomas^a ; ^b ; ^c ; ^d ; ^f ; ^{gthomas@ampiopharma.com" class="auth_mail" title="E-mail the corresponding author} ; Leonard T. Rael^a ; ^b ; ^c ; ^d ; ^f ; ^{lrael@ampiopharma.com" class="auth_mail" title="E-mail the corresponding author} ; Melissa Hausburg^a ; ^b ; ^c ; ^d ; ^f ; ^{mhausburg@ampiopharma.com" class="auth_mail" title="E-mail the corresponding author} ; Elizabeth D. Frederick^a ; ^b ; ^c ; ^d ; ^f ; ^{efredrick@ampiopharma.com" class="auth_mail" title="E-mail the corresponding author} ; Edward Brody^e ; ^{ebrody@somalogic.com" class="auth_mail" title="E-mail the corresponding author} ; David Bar-Or^a ; ^b ; ^c ; ^d ; ^f ; ^{dbaror@ampiopharma.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Endothelial cells ; Acetylated α-tubulin ; Calcium mobilization ; PI3-Kinase ; p38 MAPK ; Low molecular weight fraction of commercial 5% albumin
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：30 September 2016
年：2016
卷：478
期：4
页码：1780-1785
全文大小：1029 K

文摘

class="label">•: LMWF5A rapidly induces the acetylation of α-tubulin in retinal endothelial cells.
class="label">•: Inhibition of PI3 kinase reduces LMWF5A-induced acetylation.
class="label">•: Inhibition of p38 MAPK potentates LMWF5A-induced acetylation.
class="label">•: Calcium chelation reduces LMWF5A-induced acetylation.
class="label">•: LMWF5A reduces the transcytosis of macromolecules across endothelial cells.