Addressing the expected survival benefit for clinical trial design in metastatic castration-resistant prostate cancer: Sensitivity analysis of randomized trials.

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Addressing the expected survival benefit for clinical trial design in metastatic castration-resistant prostate cancer: Sensitivity analysis of randomized trials.

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作者：Francesco Massari^a ; ^{fmassari79@gmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Alessandra Modena^a ; ^{alessandra.modena@alice.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Chiara Ciccarese^a ; ^{ciccarese.c@gmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Sara Pilotto^a ; ^{sara.pilotto.85@alice.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Francesca Maines^g ; ^{francesca.maines@gmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Sergio Bracarda^b ; ^{sergio.bracarda@usl8.toscana.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Isabella Sperduti^c ; ^{isperduti@yahoo.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Diana Giannarelli^c ; ^{giannarelli@ifo.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Paolo Carlini^d ; ^{paolo_carlini@yahoo.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Daniele Santini^e ; ^{d.santini@unicampus.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Giampaolo Tortora^a ; ^{giampaolo.tortora@univr.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Camillo Porta^f ; ¹ ; ² ; ^{c.porta@smatteo.pv.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Emilio Bria^a ; ¹ ; ² ; ^{emilio.bria@univr.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae
关键词：Prostate cancer ; Chemotherapy ; Hormonal therapy ; Immunotherapy ; Overall survival
刊名：Critical Reviews in Oncology and Hematology
出版年：2016
出版时间：February 2016
年：2016
卷：98
期：Complete
页码：254-263
全文大小：1929 K

文摘

class="label">•: All randomized clinical trials in with patients with metastatic castration-resistant prostate cancer received systemic therapy were considered.
class="label">•: We used a meta-analytical approach to evaluate if the comparison of the trials’ results may drive to biased survival estimations.
class="label">•: Sensitivity analyses according to: 1) Therapeutic Strategy 2) Control arm and 3) Docetaxel timing were performed.
class="label">•: The data reported suggest a differential benefit in overall survival according to the three factors analyzed.