Mass spectrometric characterization of limited proteolysis activity in human plasma samples under mild acidic conditions

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Mass spectrometric characterization of limited proteolysis activity in human plasma samples under mild acidic conditions

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作者：Jingzhi Yang^a ; Claudia Rö ; wer^a ; Cornelia Koy^a ; Manuela Ruß ; ^a ; Christopher P. Rü ; ger^b ; ^c ; Ralf Zimmermann^b ; ^c ; Uwe von Fritschen^d ; Marius Bredell^e ; Juliane C. Finke^d ; Michael O. Glocker^a ; ^{michael.glocker@med.uni-rostock.de" class="auth_mail" title="E-mail the corresponding author} ;
关键词：DHB ; 2 ; 5-dihydroxybenzoic acid ; FA ; formic acid ; TFA ; trifluoroacetic acid ; ACN ; acetonitrile ; MS ; mass spectrometry ; MALDI ; matrix-assisted laser desorption/ionization ; ESI ; electrospray ionization ; ECD ; electron capture dissociation ; CID ; collisional induced dissociation ; ToF ; time of flight ; QIT ; quadrupole ion trap ; Q ; quadrupole ; ISD ; in-source decay ; FT-ICR ; Fourier transform-ion cyclotron resonance ; RF ; radio frequency ; FWHM ; full width at half maximum ; MRM ; multiple reaction monitoring
刊名：Methods
出版年：2015
出版时间：1 November 2015
年：2015
卷：89
期：Complete
页码：30-37
全文大小：490 K

文摘

class="label">•: Protease activity monitoring of patient serum samples by mass spectrometry.
class="label">•: Limited proteolysis in human plasma monitored by linear MALDI ToF MS profiling.
class="label">•: Human serum albumin is N-terminally cleaved upon dropping serum pH to 6.
class="label">•: CID fragmentation of a positively charged peptide at high pH after charge-stripping.

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