ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

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ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

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作者：Lydia M. Young^a ; ^b ; ¹ ; ^{bs08lw@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Janet C. Saunders^a ; ^b ; ¹ ; ^{bsjct@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Rachel A. Mahood^a ; ^b ; ^{bs08ram@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Charlotte H. Revill^a ; ^c ; ^{C.H.Revill@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Richard J. Foster^a ; ^c ; ^{R.Foster@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Alison E. Ashcroft^a ; ^b ; ^{A.E.Ashcroft@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Sheena E. Radford^a ; ^b ; ^{S.E.Radford@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Aβ ; amyloid-β peptide ; Aβ40 ; amyloid-β peptide residues 1&ndash ; 40 ; AD ; Alzheimer&rsquo ; s disease ; ADH ; alcohol dehydrogenase ; AFM ; atomic force microscopy ; CCS ; collision-cross sectional area ; Cl-NQTrp ; chloronaphthoquinine-tryptophan ; CsI ; caesium iodide ; DMSO ; dimethyl sulfoxide ; EGCG ; (&minus ; )-epigallocatechin gallate ; ESI-IMS&ndash ; MS ; electrospray ionisation-ion mobility spectrometry&ndash ; mass spectrometry ; HDMS ; high-definition mass spectrometry ; hIAPP ; human islet amyloid polypeptide
刊名：Methods
出版年：2016
出版时间：15 February 2016
年：2016
卷：95
期：Complete
页码：62-69
全文大小：2777 K

文摘

class="label">•: Identification of small molecule inhibitors of protein aggregation using ESI-IMS–MS.
class="label">•: Characterisation of binding mode as negative, specific, non-specific or colloidal.
class="label">•: High throughput ligand screening using ESI-IMS–MS.
class="label">•: Identification of novel small molecule inhibitors of Aβ40 aggregation.

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