Malony-CoA inhibits the S113L variant of carnitine-palmitoyltransferase II

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Malony-CoA inhibits the S113L variant of carnitine-palmitoyltransferase II

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作者：Leila Motlagh^a ; ^{leila.motlagh@medizin.uni-halle.de" class="auth_mail" title="E-mail the corresponding author} ; Ralph Golbik^b ; Wolfgang Sippl^c ; Stephan Zierz^a
关键词：CoA ; coenzyme A ; CPT I ; carnitine palmitoyltransferase I ; CPT II ; carnitine palmitoyltransferase II ; hCPT2 ; gene coding for human muscle carnitine palmitoyltransferase II ; MD ; molecular dynamics
刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
出版年：2016
出版时间：January 2016
年：2016
卷：1861
期：1
页码：34-40
全文大小：762 K

文摘

class="label">•: CPT II and not only CPT I can be inhibited by malonyl-CoA.
class="label">•: The inhibition is more pronounced for the variant S113L of this enzyme.
class="label">•: By docking studies malonyl-CoA could be shown to bind at two sites of the enzyme.

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