Fungal peptides from pneumonitis hypersensitivity etiologic agents are able to induce specific cellular immune response

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• 作者：Anne-Pauline Bellanger^a ; ^b ; ^{apbellanger@chu-besancon.fr} ; Thibaud Lignon^b ; Yann Godet^c ; Bé ; né ; dicte Rognon^a ; Gabriel Reboux^a ; ^b ; Houssein Gbaguidi-Haore^d ; Christophe Borg^c ; Laurence Millon^a ; ^b
• 关键词：HP ; hypersensitivity pneumonitis ; DLDH ; dihydrolipoyl dehydrogenase ; Lc ; Lichtheimia corymbifera ; Mi ; Mycobacterium immunogenum
• 刊名：Journal of Immunological Methods
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：67-73
• 全文大小：933 K
• 卷排序：440

文摘

The protein DLDH is common to agents of HP from different phylogenetic families Peptides ability to induce IFNγ upon stimulation of PBMC was assessed by ELISPOT A pool of peptides from MiDLDH induced a marked IFNγ specific immune response Marked IFNγ responses in blood donors suggest a previous environmental exposure Cross reactive mechanisms between environmental antigens are highly probable