Single nucleotide polymorphisms in Plasmodium falciparum V type H<sup>+</sup> pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms

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Single nucleotide polymorphisms in Plasmodium falciparum V type H⁺ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms

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作者：Irina Tatiana Jovel^a ; ^b ; ^{irina.jovel@ki.se" class="auth_mail} ; Pedro Eduardo Ferreira^c ; ^l ; ^{pedroemferreira@gmail.com" class="auth_mail} ; Maria Isabel Veiga^a ; ^d ; ^e ; ^{maria.isabel.veiga@gmail.com" class="auth_mail} ; Maja Malmberg^a ; ^m ; ^{malmberg.maja@gmail.com" class="auth_mail} ; Andreas Må ; rtensson^a ; ^f ; ^{andreas.martensson@ki.se" class="auth_mail} ; Akira Kaneko^c ; ^{akira.kaneko@ki.se" class="auth_mail} ; Sedigheh Zakeri^g ; ^{zakeris@yahoo.com" class="auth_mail} ; Claribel Murillo^h ; ^{claribel_murillo@cideim.org.co" class="auth_mail} ; Francois Nostenⁱ ; ^j ; ^k ; ^{francois@tropmedres.ac" class="auth_mail} ; Anders Bjö ; rkman^a ; ^{anders.bjorkman@karolinska.se" class="auth_mail} ; Johan Ursing^a ; ^{johan.ursing@karolinska.se" class="auth_mail}
关键词：P. falciparum ; Malaria ; Pfcrt ; Pfmdr1 ; Pfvp2 ; Chloroquine ; Resistance
刊名：Infection, Genetics and Evolution
出版年：June 2014
年：2014
卷：24
期：Complete
页码：111-115
全文大小：294 K

文摘

•: First report on pfvp2 SNPs and their possible associations with pfcrt and pfmdr1.
•: Pfvp2 V405, K582 and P711 alleles were predominant in all eight countries studied.
•: Pfvp2 405I, 582R and 711S were mainly seen in areas where CQ resistance was uncommon.
•: There was an association between the pfvp2 VKP haplotype and CQ resistance pfcrt 76T.