Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

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Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

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作者：Ashwani Sharma¹ ; ⁵ ; Amol Aher² ; ⁵ ; Nicola J. Dynes³ ; ⁵ ; Daniel Frey¹ ; Eugene A. Katrukha² ; Rolf Jaussi¹ ; Ilya Grigoriev² ; Marie Croisier⁴ ; Richard A. Kammerer¹ ; Anna Akhmanova² ; ^{a.akhmanova@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Pierre Gö ; nczy³ ; ^{pierre.gonczy@epfl.ch" class="auth_mail" title="E-mail the corresponding author} ; Michel O. Steinmetz¹ ; ^{michel.steinmetz@psi.ch" class="auth_mail" title="E-mail the corresponding author}
关键词：Centrioles ; microtubules ; CPAP/SAS-4 ; in vitro reconstitutions ; human cells ; X-ray crystallography
刊名：Developmental Cell
出版年：2016
出版时间：23 May 2016
年：2016
卷：37
期：4
页码：362-376
全文大小：6351 K

文摘

•: CPAP's PN2-3 domain binds to an exposed site on β-tubulin at microtubule plus ends
•: CPAP tracks and caps microtubule plus ends in vitro
•: CPAP dampens microtubule growth in vitro
•: The capping function of CPAP limits centriolar microtubule growth in human cells

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