New modified multiwalled carbon nanotubes paste electrode for electrocatalytic oxidation and determination of warfarin in biological and pharmaceutical samples

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• 作者：Masoumeh Taei ; ^{m.taei@ch.iut.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{m_taei57@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Fardin Abedi
• 关键词：ZnCrFeO4 ; Multiwalled carbon nanotubes ; Warfarin ; Electrochemical impedance spectroscopy ; Paste electrode
• 刊名：Chinese Journal of Catalysis
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：37
• 期：3
• 页码：436-445
• 全文大小：2409 K

文摘

A novel sensor for the determination of warfarin based on a simple and sensitive method was developed on multiwalled-carbon-nanotube modified ZnCrFeO₄ carbon paste electrodes (MWCNT/ZnCrFeO₄/CPEs). Cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of warfarin at the chemically modified electrode. According to the results, MWCNT/ZnCrFeO₄/CPEs showed high electrocatalytic activity for warfarin oxidation, producing a sharp oxidation peak current at about +0.97 vs Ag/AgCl reference electrode at pH = 4.0. The peak current was linearly dependent on warfarin concentration over the range of 0.02–920.0 μmol/L with a detection limit of 0.003 μmol/L. In addition, chronoamperometry was also used to determine warfarin's catalytic rate constant and diffusion coefficient at MWCNT/ZnCrFeO₄/CPEs.