The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes

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The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes

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作者：Thomas Tischer¹ ; Melina Schuh¹ ; ² ; ³ ; ^{melina.schuh@mpibpc.mpg.de" class="auth_mail" title="E-mail the corresponding author}
关键词：mouse oocytes ; meiosis ; DUSP7 ; phosphatase ; PKC ; chromosome segregation ; prophase arrest
刊名：Cell Reports
出版年：2016
出版时间：25 October 2016
年：2016
卷：17
期：5
页码：1426-1437
全文大小：3731 K

文摘

•: The phosphatase DUSP7 is an essential regulator of meiotic resumption
•: DUSP7 dephosphorylates and inactivates cPKC isoforms
•: Inactivation of cPKC isoforms is essential for the timely activation of Cdk1/CycB

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