Introducing basic knowledge on STAT3 and briefly summarize the activation, inactivation, and regulation of STAT3 pathway.

Describing the activation of STAT3 following cerebral ischemia and hemorrhage.

Summarizing several significant cerebral ischemic and hemorrhagic stroke treatments that target the STAT3 signaling pathway, including drug and physical therapy.

Discussing the physiopathological roles of STAT3 in cerebral ischemia and hemorrhage and highlighting research progress on STAT3 in stroke.

This review presents a comprehensive picture of the role of STAT3 in the nervous system and may contribute to the promotion of STAT3 as a new therapeutic target.