Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial

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Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial

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作者：Deanna M. Barch^a ; ^c ; ⁱ ; ^{dbarch@wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; Stephen R. Marder^b ; ^j ; ^{SMarder@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author} ; Michael P. Harms^c ; ^{mharms@wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; L. Fredrik Jarskog^d ; ^{lars_jarskog@med.unc.edu" class="auth_mail" title="E-mail the corresponding author} ; Robert W. Buchanan^e ; ^{rwbuchanan@mprc.umaryland.edu" class="auth_mail" title="E-mail the corresponding author} ; Will Cronenwett^f ; ^{w-cronenwett@northwestern.edu" class="auth_mail" title="E-mail the corresponding author} ; Li-Shiun Chen^c ; ^{chenli@psychiatry.wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; Markus Weiss^g ; ^{markus.weiss@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Ralph P. Maguire^g ; ^{paul.maguire@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Nicole Pezous^g ; ^{nicole.pezous@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Dominik Feuerbach^g ; ^{dominik.feuerbach@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Cristina Lopez-Lopez^g ; ^{cristina.lopez_lopez@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Donald R. Johns^g ; ^{donald.johns@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Rhett B. Behrje^g ; ^{rhett.behrje@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Baltazar Gomez-Mancilla^g ; ^h ; ^{baltazar.gomezmancilla@novartis.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AE ; Adverse event ; ant. ; Anterior ; ASL ; Arterial Spin Labeling ; BOLD ; Blood-oxygenation-level dependent ; CBF ; Cerebral blood flow ; CI ; Confidence interval ; CYP ; Cytochrome P450 ; DOF ; Degree of freedom ; EMT ; Episodic memory task ; EV ; Explanatory variables ; fBIRN ; Functional Bioinformatics Research Network ; FEAT ; fMRI Expert Analysis Tool ; fMRI ; Functional magnetic resonance imaging ; FSL ; Functional Software Library ; GLM ; General Linear Modeling ; Hippo. ; Hippocampus ; MCCB ; MATRICS Consensus Cognit
刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
出版年：2016
出版时间：3 November 2016
年：2016
卷：71
期：Complete
页码：66-75
全文大小：504 K

文摘

•: Randomized, double-blind, placebo-controlled imaging study in schizophrenia
•: Performance of working and episodic memory tasks associated with brain activation
•: AQW051 (7.5 mg) associated with significant effects on episodic memory vs placebo
•: AQW051 did not significantly improve working memory in study participants.
•: AQW051 was well tolerated with an acceptable safety profile.