Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells

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作者：Pooja Dhupkar^a ; ^b ; Huang Zhao^a ; Kalpana Mujoo^a ; ¹ ; Zhiqiang An^a ; ^b ; Ningyan Zhang^a ; ^{ningyan.zhang@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Crk II ; Prostate cancer ; IGF-1R
刊名：Biochemistry and Biophysics Reports
出版年：2016
出版时间：December 2016
年：2016
卷：8
期：Complete
页码：382-388
全文大小：1126 K

文摘

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Blocking Crk II inhibited cancer cell migration, invasion, and colony formation.

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Knockdown Crk II decreased IGF-1R protein and its downstream signaling.

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Crk II knockdown increased ubiquitination and degradation of IGF-1R.