Development of simultaneous control of polymorphism and morphology in indomethacin crystallization

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Development of simultaneous control of polymorphism and morphology in indomethacin crystallization

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作者：Shuichi Wada ; ^{50014832702@st.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shoji Kudo ; Hiroshi Takiyama
关键词：A1. Polymorphism ; A1. Solubility ; A2. Industrial crystallization ; A2. Growth from solution ; B1. Organic compounds
刊名：Journal of Crystal Growth
出版年：2016
出版时间：1 February 2016
年：2016
卷：435
期：Complete
页码：37-41
全文大小：1686 K

文摘

•: Anti-solvent crystallization was carried out for indomethacin (IMC).
•: Dispersion of droplets was obtained by using NaCl aq. solution as the anti-solvent.
•: IMC cotton agglomerates was modified by using the dispersion of droplets.
•: Simultaneous control method of polymorphism and morphology for IMC was proposed.

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