Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

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• 作者：Grzegorz Mlostoń^a ; Katarzyna Urbaniak^a ; Greta Utecht^a ; Dieter Lentz^b ; Marcin Jasiński^a ; ^{mjasinski@uni.lodz.pl}
• 关键词：Nitrile imines ; Thioketones ; [3+2]-Cycloaddition ; Fluoroalkylated N ; S-heterocycles ; 1 ; 3 ; 4-Thiadiazoles
• 刊名：Journal of Fluorine Chemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：192
• 期：part_PA
• 页码：147-154
• 全文大小：733 K
• 卷排序：192

文摘

First examples of 1,3,4-thiadiazole derivatives functionalized with the CF3 group at the C(5) atom were prepared by [3+2]-cycloadditions of the in situ generated fluorinated nitrile imines onto selected thioketones. The reactions proceeded in high yields, in a fully regioselective manner, and with a remarkable tolerance to functional group present in the starting nitrile imine.