Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration

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• 作者：Mar&iacute ; a F. Coronel^a ; Marcelo J. Villar^b ; Pablo R. Brumovsky^b ; ^{pablo_brumovsky@yahoo.com} ; Susana L. Gonz&aacute ; lez^a ; ^c ; ^{sugnzlz@gmail.com}
• 关键词：CGRP ; Calcitonin gene related peptide ; CycB ; cyclophilin B ; CTL ; control animals ; DRGs ; dorsal root ganglia ; HX ; hemisected animals ; X&thinsp ; +&thinsp ; P ; Ghemisected animals treated with progesterone ; NPY ; neuropeptide Y ; PCR ; polymerase chain reaction ; PG ; progesterone ; SCI ; spinal cord injury
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：189-195
• 全文大小：891 K
• 卷排序：88

文摘

Neuropathic pain elicited by spinal cord injury (SCI) is refractory to treatment. SCI induces changes in the spinal expression of Galanin, NPY and their receptors. These neuropeptide systems may be involved in an endogenous protective response. Progesterone (PG) prevents the injury-induced changes in neuropeptide expression. PG prevents allodynia and emerges as an attractive strategy to prevent chronic pain.