Recanalization t
herapies suc
h as intravenous t
hrombolysis (IVT) or endovascular treatment (EVT) improve acute isc
hemic stroke outcomes;
however, t
hey carry t
he risk of intracranial
hemorr
hage (ICH). T
he present study assessed t
he frequency and predictive factor of ICH in Japanese patients wit
h acute large vessel occlusion.<
h4 id="absSec_2">Met
hods
h4>
The Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Registry prospectively registered 1442 stroke patients with major vessel occlusion who were admitted to 84 Japanese stroke centers within 24 hours after onset, from July 2010 to June 2011. Among these 1442 patients, 1357 were included to evaluate the incidence rate and predictive factors of ICH within 24 hours after onset.
<
h4 id="absSec_3">Results
h4>
ICH was observed in 284 (20.9%) patients. Among these patients, 46 (3.4%) had symptomatic ICH, and its incidence was higher in the recanalization therapy (IVT and/or EVT) group than in the conservative therapy group (4.5% versus 2.1%, P = .013). On multivariate analyses, symptomatic ICH was related to pretreatment antiplatelet agent use and systemic heparinization, and was related to neither IVT nor EVT.
<
h4 id="absSec_4">Conclusions
h4>
Symptomatic ICH was not affected by recanalization therapy or EVT itself in Japanese patients with acute large vessel occlusion.