Contribution of the C-Terminal Region of a Group II Chaperonin to its Interaction with Prefoldin and Substrate Transfer

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Contribution of the C-Terminal Region of a Group II Chaperonin to its Interaction with Prefoldin and Substrate Transfer

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作者：Tamotsu Zako¹ ; ^&dagger ; ; ⁴ ; Muhamad Sahlan² ; ³ ; ^&dagger ; ; Sayaka Fujii² ; ^&dagger ; ; Yohei Y. Yamamoto² ; ^&dagger ; ; Phan The Tai² ; Kotaro Sakai¹ ; ² ; Mizuo Maeda¹ ; Masafumi Yohda² ; ^{yohda@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：CPN ; chaperonin ; T.KS-1 ; hyperthermophilic archaeon Thermococcus sp. strain KS-1 ; PFD ; prefoldin ; PFDα1β1 ; prefoldin of Thermococcus sp. strain KS-1 composed of α1 and β1 subunits ; PFDα2β2 ; prefoldin of Thermococcus sp. strain KS-1 composed of α2 and β2 subunits ; CS ; citrate synthase from porcine heart ; GFP ; green fluorescent protein ; SPR ; surface plasmon resonance ; PAGE ; polyacrylamide gel electrophoresis ; CPNβ ; T.KS-1 chaperonin β homo-oligomer ; CPNβTc1 ; T.KS-1 chaperonin β mutant with the tru
刊名：Journal of Molecular Biology
出版年：2016
出版时间：5 June 2016
年：2016
卷：428
期：11
页码：2405-2417
全文大小：1020 K

文摘

•: Prefoldin (PFD) interacts with group II chaperonin (CPN) for substrate transfer.
•: The flexible C-terminal region of CPN protrudes into the cavity of CPN.
•: Truncation of the CPN C-terminal region decreases affinity with PFD.
•: Truncation also decreases substrate transfer from PFD and folding by CPN.
•: The C-terminal region of CPN is a newly found interaction site with PFD.

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