Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

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• 作者：Marvin J. Slepian^a ; ^b ; ^{chairman.syns@gmail.com} ; Jawaad Sheriff^b ; Marcus Hutchinson^a ; Phat Tran^a ; Naing Bajaj^a ; Joe G.N. Garcia^a ; S. Scott Saavedra^c ; Danny Bluestein^b
• 关键词：Mechanotransduction ; Platelet activation ; Mechanical circulatory support ; Thrombosis ; Fluid shear stress
• 刊名：Journal of Biomechanics
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：20-25
• 全文大小：1130 K
• 卷排序：50

文摘

Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.