Impaired cued and spatial learning performance and altered cannabinoid CB<sub>1</sub> receptor functionality in the substantia nigra in a rat model of diabetic neuropathy

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Impaired cued and spatial learning performance and altered cannabinoid CB₁ receptor functionality in the substantia nigra in a rat model of diabetic neuropathy

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作者：Orla Moriarty^a ; ^c ; ^d ; ¹ ; Yvonne Lang^a ; ^c ; ^d ; ¹ ; Zubair Idrees^f ; Brian E. McGuire^b ; ^c ; ^d ; ^e ; David P. Finn^a ; ^c ; ^d ; ^e ; ² ; ^{david.finn@nuigalway.ie" class="auth_mail" title="E-mail the corresponding author}
关键词：Diabetes ; Streptozotocin ; Neuropathic pain ; Morris water maze ; Cannabinoid1 (CB1) receptor ; [35S]GTPγS binding
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 April 2016
年：2016
卷：303
期：Complete
页码：61-70
全文大小：1415 K

文摘

•: STZ-treated rats developed mechanical allodynia and thermal hypoalgesia.
•: STZ-treated rats showed impaired cued and reference learning in the water maze.
•: CB₁ receptor functionality was altered in the substantia nigra of STZ-treated rats.