Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

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Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

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作者：Jianqiang Wu¹ ; Vincent W. Keng³ ; ⁴ ; ⁵ ; ¹³ ; Deanna M. Patmore¹ ; Jed J. Kendall¹ ; Ami V. Patel¹ ; Edwin Jousma¹ ; Walter J. Jessen¹ ; Kwangmin Choi¹ ; Barbara R. Tschida³ ; ⁵ ; Kevin A.T. Silverstein⁶ ; Danhua Fan⁶ ; Eric B. Schwartz⁷ ; James R. Fuchs⁷ ; Yuanshu Zou² ; Mi-Ok Kim² ; Eva Dombi⁸ ; David E. Levy⁹ ; Gang Huang¹ ; Jose A. Cancelas¹ ; ¹⁰ ; Anat O. Stemmer-Rachamimov¹¹ ; Robert J. Spinner¹² ; David A. Largaespada³ ; ⁴ ; ⁵ ; Nancy Ratner¹ ; ^{nancy.ratner@cchmc.org" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：1 March 2016
年：2016
卷：14
期：8
页码：1979-1990
全文大小：4094 K

文摘

•: Insertional mutagenesis identifies STAT3 as a driver of benign neurofibromas
•: Stat3 activates β-catenin to initiate neurofibroma formation
•: Stat3 represses Gsk3β and Arid1b to increase β-catenin
•: Neurofibroma-initiating cells require Stat3 and β-catenin for tumorigenesis

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