Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model

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Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model

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作者：Renata P. Lerner^a ; ^{rlerner@nshs.edu" class="auth_mail" title="E-mail the corresponding author} ; Zisis Bimpisidis^b ; ^{zisis.bimpisidis@med.lu.se" class="auth_mail" title="E-mail the corresponding author} ; Stergiani Agorastos^a ; ^{sagorastos1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sandra Scherrer^a ; ^{sassyhippy76@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Stephen L. Dewey^a ; ^{sdewey@nshs.edu" class="auth_mail" title="E-mail the corresponding author} ; M. Angela Cenci^b ; ^{angela.cenci_nilsson@med.lu.se" class="auth_mail" title="E-mail the corresponding author} ; David Eidelberg^a ; ^{david1@nshs.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BBB ; blood brain barrier ; 6-OHDA ; 6-hydroxydopamine ; PD ; Parkinson's disease ; H215O ; 15O-water ; FDG ; 18F-fluorodeoxyglucose ; CBF ; cerebral blood flow ; CMR ; cerebral metabolic rate for glucose ; GP ; globus pallidus ; LID ; levodopa-induced dyskinesia ; VOI ; volume-of-interest ; DI ; dissociation index ; EP ; enteropeduncular nucleus ; M2 ; auxiliary motor cortex
刊名：Neurobiology of Disease
出版年：2016
出版时间：December 2016
年：2016
卷：96
期：Complete
页码：31-37
全文大小：658 K

文摘

•: In vivo measurements of cerebral blood flow and metabolism in the 6-OHDA rat model
•: Dissociated response of blood flow and metabolism to acute levodopa challenge
•: Levodopa response driven by significant increases in blood flow
•: MicroPET approach will have utility for studying levodopa-induced dyskinesias

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