Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types

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Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types

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作者：Vitor Onuchic¹ ; ⁶ ; ^{onuchic@bcm.edu" class="auth_mail" title="E-mail the corresponding author} ; Ryan J. Hartmaier² ; ⁷ ; David N. Boone² ; Michael L. Samuels³ ; Ronak Y. Patel¹ ; Wendy M. White⁴ ; Vesna D. Garovic⁵ ; Steffi Oesterreich² ; Matt E. Roth¹ ; Adrian V. Lee² ; Aleksandar Milosavljevic¹ ; ⁶ ; ⁸ ; ^{amilosav@bcm.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：cell type composition ; deconvolution ; breast cancer ; metabolic coupling ; heterotypic interaction ; DNA methylation ; gene expression ; Warburg effect ; cancer ; metabolism
刊名：Cell Reports
出版年：2016
出版时间：15 November 2016
年：2016
卷：17
期：8
页码：2075-2086
全文大小：4250 K

文摘

•: EDec infers cell types within tissues and molecular profiles of constituent cells
•: EDec deconvolutes molecular profiles of breast tumors within the TCGA collection
•: EDec-estimated immune infiltration predicts prognosis for basal-like breast tumors
•: Switch from adipose to fibrous stroma enhances oxidative metabolism of cancer cells

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