Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

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Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

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作者：Andrew J. Kennedy¹ ; ² ; Elizabeth J. Rahn¹ ; Brynna S. Paulukaitis¹ ; ⁵ ; Katherine E. Savell¹ ; Holly B. Kordasiewicz³ ; Jing Wang¹ ; John W. Lewis¹ ; Jessica Posey¹ ; Sarah K. Strange¹ ; Mikael C. Guzman-Karlsson¹ ; Scott E. Phillips¹ ; Kyle Decker¹ ; S. Timothy Motley⁴ ; Eric E. Swayze³ ; David J. Ecker⁴ ; Todd P. Michael⁴ ; Jeremy J. Day¹ ; J. David Sweatt¹ ; ⁵ ; ⁶ ; ^{david.sweatt@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：epigenetics ; Pitt-Hopkins syndrome ; transcription factor 4 ; E2-2 ; neuroepigenetics ; DNA methylation ; learning and memory ; next-generation sequencing ; HDAC inhibitor ; schizophrenia ; language ; transcription ; autism ; social interactions ; autism spectrum disorder
刊名：Cell Reports
出版年：2016
出版时间：6 September 2016
年：2016
卷：16
期：10
页码：2666-2685
全文大小：3561 K

文摘

•: A Tcf4(+/−) mouse model is reported for Pitt-Hopkins syndrome (PTHS)
•: HDAC inhibition rescues learning and memory deficits of PTHS mice
•: Hdac2 is a therapeutic target for cognitive enhancement
•: Genes with altered mRNA and CpG Me due to learning are dysregulated in PTHS

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