Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

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Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

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作者：Hui Zhang¹ ; ¹⁵ ; Tao Liu² ; ¹⁵ ; Zhen Zhang¹ ; ¹⁵ ; Samuel H. Payne² ; ¹⁵ ; Bai Zhang¹ ; Jason E. McDermott² ; Jian-Ying Zhou¹ ; Vladislav A. Petyuk² ; Li Chen¹ ; Debjit Ray² ; Shisheng Sun¹ ; Feng Yang² ; Lijun Chen¹ ; Jing Wang³ ; Punit Shah¹ ; Seong Won Cha⁴ ; Paul Aiyetan¹ ; Sunghee Woo⁴ ; Yuan Tian¹ ; Marina A. Gritsenko² ; Therese R. Clauss² ; Caitlin Choi¹ ; Matthew E. Monroe² ; Stefani Thomas¹ ; Song Nie² ; Chaochao Wu² ; Ronald J. Moore² ; Kun-Hsing Yu⁵ ; ⁶ ; David L. Tabb³ ; David Fenyö ; ⁷ ; Vineet Bafna⁸ ; Yue Wang⁹ ; Henry Rodriguez¹⁰ ; Emily S. Boja¹⁰ ; Tara Hiltke¹⁰ ; Robert C. Rivers¹⁰ ; Lori Sokoll¹ ; Heng Zhu¹ ; Ie-Ming Shih¹¹ ; Leslie Cope¹² ; Akhilesh Pandey¹³ ; Bing Zhang³ ; Michael P. Snyder⁶ ; Douglas A. Levine¹⁴ ; Richard D. Smith² ; Daniel W. Chan¹ ; ¹⁶ ; ^{dchan@jhmi.edu" class="auth_mail" title="E-mail the corresponding author} ; Karin D. Rodland² ; ¹⁶ ; ^{karin.rodland@pnnl.gov" class="auth_mail" title="E-mail the corresponding author} ; the CPTAC InvestigatorsSteven A. Carr ; Michael A. Gillette ; Karl R. Klauser ; Eric Kuhn ; D.R. Mani ; Philipp Mertins ; Karen A. Ketchum ; Ratna Thangudu ; Shuang Cai ; Mauricio Oberti ; Amanda G. Paulovich ; Jeffrey R. Whiteaker ; Nathan J. Edwards ; Peter B. McGarvey ; Subha Madhavan ; Pei Wang ; Daniel W. Chan ; Akhilesh Pandey ; Ie-Ming Shih ; Hui Zhang ; Zhen Zhang ; Heng Zhu ; Leslie Cope ; Gordon A. Whiteley ; Steven J. Skates ; Forest M. White ; Douglas A. Levine ; Emily S. Boja ; Christopher R. Kinsinger ; Tara Hiltke ; Mehdi Mesri ; Robert C. Rivers ; Henry Rodriguez ; Kenna M. Shaw ; Stephen E. Stein ; David Fenyo ; Tao Liu ; Jason E. McDermott ; Samuel H. Payne ; Karin D. Rodland ; Richard D. Smith ; Paul Rudnick ; Michael Snyder ; Yingming Zhao ; Xian Chen ; David F. Ransohoff ; Andrew N. Hoofnagle ; Daniel C. Liebler ; Melinda E. Sanders ; Zhiao Shi ; Robbert J.C. Slebos ; David L. Tabb ; Bing Zhang ; Lisa J. Zimmerman ; Yue Wang ; Sherri R. Davies ; Li Ding ; Matthew J.C. Ellis ; R. Reid Townsend
刊名：Cell
出版年：2016
出版时间：28 July 2016
年：2016
卷：166
期：3
页码：755-765
全文大小：3164 K

文摘

•: Comprehensive proteomic characterization of 174 ovarian tumors are analyzed
•: Copy-number alterations affect the proteome in trans, converging on pathways
•: Acetylation of histone H4 correlates with homologous repair deficiency status
•: Protein and phosphoprotein abundance identifies pathways associated with survival