刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:3221-3236
全文大小:1431 K
卷排序:1861
文摘
Oxamate, aminooxyacetate (AOA) and dichloroacetate (DCA) are not specific drugs. Oxamate, AOA and DCA inhibit several glycolytic and OxPhos enzymesOxamate inhibition induces Fru1,6BP and DHAP accumulation. High Fru1,6BP and DAHP levels inhibit HK, HPI, TPI and GAPDH activities. Kinetic modeling shows that oxamate must affect several enzymes to block glycolysis.
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