Drosophila miR-956 suppression modulates Ectoderm-expressed 4 and inhibits viral replication

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• 作者：Verna Monsanto-Hearne ; Annabelle L.Y. Tham ; Zhee Sheen Wong ; Sassan Asgari ; Karyn N. Johnson ; ^{karynj@uq.edu.au}
• 关键词：Host-virus interaction ; Insect-virus interaction ; miRNA ; Drosophila ; Drosophila C virus ; Ect4 ; Dicistroviridae
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：20-27
• 全文大小：594 K
• 卷排序：502

文摘

Drosophila C virus (DCV) infection in model host Drosophila impacts miRNA abundance. Abundance of miR-956-3p is decreased in adult flies following DCV infection. DCV-induced morality is delayed in mutant flies lacking miR-956. miR-956-3p modulates levels of host Ectoderm-expressed 4 (ect4) mRNA. DCV-induced mortality is earlier in mutant flies with reduced Ect4 expression.