Analysis of gene expression in Ca²⁺-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways

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• 作者：Tetsushi Sadakata^a ; ^{sadakata-1024@umin.ac.jp} ; Yo Shinoda^d ; Yasuki Ishizaki^c ; Teiichi Furuichi^b
• 关键词：CADPS2 CAPS2 ; Ca2+-dependent activator protein for secretion 2 ; SV ; synaptic vesicle ; DCV ; dense-core vesicle ; BDNF ; brain-derived neurotrophic factor ; NT-3 ; neurotrophin-3 ; WT ; wild-type ; KO ; knockout ; KD ; knockdown ; GO ; gene ontology ; SOS ; son of sevenless
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：88-93
• 全文大小：1518 K
• 卷排序：639

文摘

We analyzed gene expression in the Cadps2 KO cerebellum with a GeneChip microarray. Significant differential expression was observed in 5.34% of genes on the GeneChip. Expression of many secretory proteins was changed in the Cadps2 KO cerebellum. The neurotrophin signaling pathway was impaired in the Cadps2 KO cerebellum.