Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis

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• 作者：Cory M. Dungan ; David L. Williamson ; ^{dlw125@psu.edu}
• 关键词：Insulin signaling ; REDD1 ; PD184352 ; Rapamycin ; Skeletal muscle
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1067-1072
• 全文大小：998 K
• 卷排序：482

文摘

A loss of REDD1 reduces skeletal muscle insulin-stimulated insulin signaling. MEK1/2 inhibition in REDD1 wildtype mice reduces REDD1 and skeletal muscle insulin-stimulated insulin signaling. mTOR inhibition in REDD1 knockout mice improves skeletal muscle insulin-stimulated insulin signaling. This work provides further support for the role of REDD1 in insulin signaling.