Endocrine and paracrine regulation of meiotic cell cycle progression in teleost oocytes: cAMP at the centre of complex intra-oocyte signalling events

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• 作者：Debabrata Das ; Pragya Paramita Khan ; Sudipta Maitra ; ^{smaitra3@gmail.com} ; ^{sudipta.maitra@visva-bharati.ac.in}
• 关键词：cAMP ; PKA ; MEK/MAPK ; Meiosis ; Oocyte ; Teleosts
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：33-40
• 全文大小：1031 K
• 卷排序：241

文摘

E2 through GPER-Gαs-adenylyl cyclase maintains high intra-oocyte cAMP/PKA in immature oocyte. Active PKA blocks translational activation and/or MEK-MAPK cascade in teleost oocyte. MIS action through mPR down regulates adenylyl cyclase and cAMP/PKA. Conversely, insulin/IGF through RTK activates PI3K/Akt/PDE3 to attenuate PKA action. Synergism between MIS and IGF1 overcomes E2-inhibition of meiosis resumption efficiently.