Exopolysaccharide from Trichoderma pseudokoningii induces the apoptosis of MCF-7 cells through an intrinsic mitochondrial pathway

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Exopolysaccharide from Trichoderma pseudokoningii induces the apoptosis of MCF-7 cells through an intrinsic mitochondrial pathway

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作者：Guodong Wang^a ; ^b ; ¹ ; Chunyan Liu^b ; ¹ ; Jun Liu^a ; Bo Liu^a ; Ping Li^b ; Guozheng Qin^b ; Yanghui Xu^b ; Ke Chen^a ; Huixia Liu^a ; ^{lhx900@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Kaoshan Chen^b ; ^c ; ^{ksc313@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Dimethyl sulfoxide (PubChem CID ; 679) ; Propidium iodide (PubChem CID ; 104981) ; Hoechst 33258 (PubChem CID ; 5491656) ; JC-1 (PubChem CID ; 5492929) ; DCFH-DA (PubChem CID ; 77718)
刊名：Carbohydrate Polymers
出版年：2016
出版时间：20 January 2016
年：2016
卷：136
期：Complete
页码：1065-1073
全文大小：2803 K

文摘

•: Exopolysaccharide (EPS) could inhibit the proliferation of MCF-7 cells and induce lactic dehydrogenase release in vivo.
•: EPS induces apoptosis and arrests MCF-7 cells in S phase of the cell cycle.
•: EPS may trigger apoptosis through an intrinsic mitochondrial apoptotic pathway.

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