Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

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Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

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作者：Guillaume B.E. Stewart-Jones¹ ; Cinque Soto¹ ; Thomas Lemmin¹ ; ² ; Gwo-Yu Chuang¹ ; Aliaksandr Druz¹ ; Rui Kong¹ ; Paul V. Thomas¹ ; Kshitij Wagh³ ; Tongqing Zhou¹ ; Anna-Janina Behrens⁴ ; Tatsiana Bylund¹ ; Chang W. Choi¹ ; Jack R. Davison⁵ ; Ivelin S. Georgiev¹ ; M. Gordon Joyce¹ ; Young Do Kwon¹ ; Marie Pancera¹ ; Justin Taft¹ ; Yongping Yang¹ ; Baoshan Zhang¹ ; Sachin S. Shivatare⁶ ; Vidya S. Shivatare⁶ ; Chang-Chun D. Lee⁶ ; Chung-Yi Wu⁶ ; Carole A. Bewley⁵ ; Dennis R. Burton⁷ ; ⁸ ; Wayne C. Koff⁹ ; Mark Connors¹⁰ ; Max Crispin⁴ ; Ulrich Baxa¹¹ ; Bette T. Korber³ ; Chi-Huey Wong⁶ ; ¹² ; John R. Mascola¹ ; Peter D. Kwong¹ ; ^{pdkwong@nih.gov" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2016
出版时间：5 May 2016
年：2016
卷：165
期：4
页码：813-826
全文大小：6077 K

文摘

•: Crystallographic (3.4–3.7 Å) visualization of the HIV-1 glycan shield
•: Structures delineate a taxonomy of N-linked glycan-glycan interactions
•: Crowded and dispersed glycans are differently ordered, processed, and conserved
•: HIV-1-neutralizing antibodies recognizing the closed Env trimer accommodate glycan

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