Uridine homeostatic disorder leads to DNA damage and tumorigenesis

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Uridine homeostatic disorder leads to DNA damage and tumorigenesis

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作者：Zhe Cao^a ; ^b ; ¹ ; Jun Ma^c ; ¹ ; Xinchun Chen^b ; Boping Zhou^b ; Chuan Cai^d ; Dan Huang^d ; Xuewen Zhang^a ; ^{xwzhang@hunan.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Deliang Cao^a ; ^c ; ^d ; ^{dcao@siumed.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ATM ; ataxia telangiectasia mutated ; ATP ; adenosine triphosphate ; ATR ; ATM-Rad3-related ; BER ; base excision repair ; CTP ; cytidine 5&prime ; -triphosphate ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; dCDP ; deoxycytidine 5&prime ; -diphosphate ; dCTP ; deoxycytidine 5&prime ; -triphosphate ; DDR ; DNA damage response ; dTMP ; deoxythymidylate ; dTTP ; deoxythymidine 5&prime ; -triphosphate ; dUMP ; deoxyuridylate ; dUTP ; 2&prime ; -deoxyuridine ; 5&prime ; -triphosphate ; FLARE assay ; fragment length analysis using repair en
刊名：Cancer Letters
出版年：2016
出版时间：28 March 2016
年：2016
卷：372
期：2
页码：219-225
全文大小：1745 K

文摘

•: Uridine homeostatic disorder induced by uridine phosphorylase knockout leads to DNA damage and spontaneous tumorigenesis.
•: Addition of uridine into culture medium causes uracil DNA damage and p53-mediated DNA damage response (DDR).
•: Pharmacological use of uridine may be carcinogenic, and the far-reaching effects need to be considered.

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