Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

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• 作者：Suet Ching Chen^a ; ^b ; Rebecca Brooks^a ; Jessica Houskeeper^b ; Shaun K. Bremner^b ; Julia Dunlop^b ; Benoit Viollet^d ; Pamela J. Logan^c ; Ian P. Salt^c ; S. Faisal Ahmed^a ; Stephen J. Yarwood^e ; ^{S.Yarwood@hw.ac.uk}
• 关键词：Adipogenesis ; Osteogenesis ; Metformin ; Diabetes ; AMPK ; Mesenchymal stem cells
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：57-68
• 全文大小：3446 K
• 卷排序：440

文摘

Metformin can inhibit adipogenesis through AMPK-dependent or -independent mechanisms, depending on the cellular context. Metformin suppresses adipogenesis in C3H10T1/2 mesenchymal stem cells (MSCs), independently of AMPK. Metformin exerts reciprocal control over osteogenic (Runx2) and adipogenic (PPARγ) transcription factors in MSCs. Basal AMPK and mTOR/p70S6K activity are required for adipogenesis in MSCs.