Tropheryma whipplei aortic valve endocarditis without systemic Whipple's disease

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• 作者：Vincent Chan^a ; Bing Wang^b ; John P. Veinot^b ; Kathryn N. Suh^c ; Gregory Rose^c ; Marc Desjardins^b ; Thierry G. Mesana^a ;   ; ^{tmesana@ottawaheart.ca}
• 关键词：Aortic valve ; Endocarditis ; Whipple's
• 刊名：International Journal of Infectious Diseases
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：15
• 期：11
• 页码：e804-e806
• 全文大小：612 K

文摘

Summary

Culture-negative endocarditis is most often the result of prior antimicrobial therapy. Tropheryma whipplei is the etiologic agent of Whipple's disease, which is typically characterized by diarrhea, weight loss, and intra-abdominal lymphadenopathy. We present the case of a 48-year-old male with Whipple's endocarditis of the aortic valve who did not develop signs of systemic Whipple's disease. Our patient was treated with a regimen that included ceftriaxone for 6 weeks prior to his cardiac surgery, yet valve pathology demonstrated abundant T. whipplei, suggesting that a prolonged antibiotic course is necessary for the treatment of Whipple's endocarditis.