Blood and salivary-gland BAFF-driven B-cell hyperactivity is associated to rituximab inefficacy in primary Sjögren's syndrome

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Blood and salivary-gland BAFF-driven B-cell hyperactivity is associated to rituximab inefficacy in primary Sjögren's syndrome

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作者：Divi Cornec^a ; ^b ; Sebastian Costa^c ; Valé ; rie Devauchelle-Pensec^a ; ^b ; Sandrine Jousse-Joulin^a ; ^b ; Pascale Marcorelles^c ; Jean-Marie Berthelot^d ; Laurent Chiche^e ; Eric Hachulla^f ; Pierre-Yves Hatron^f ; Vincent Goeb^g ; Olivier Vittecoq^h ; Alain Saraux^a ; ^b ; Jacques-Olivier Pers^b ; ^{pers@univ-brest.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Sjö ; gren's syndrome ; Primary ; Rituximab ; Histology ; B cells ; BAFF ; Treatment efficacy
刊名：Journal of Autoimmunity
出版年：2016
出版时间：February 2016
年：2016
卷：67
期：Complete
页码：102-110
全文大小：1017 K

文摘

•: The clinical response to rituximab is highly heterogeneous in pSS.
•: The pattern and timing of B-cell depletion is similar in blood and salivary glands.
•: The duration of B-cell depletion is not associated with rituximab clinical efficacy.
•: BAFF drives B-cell hyperactivity and resistance to rituximab in half of the patients.

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