Anoxia ameliorates the dexamethasone-induced neurobehavioral alterations in the neonatal male rat pups

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• 作者：Petr N. Menshanov^a ; ^b ; ^{MenshanovPN@icg.sbras.ru} ; ^{pn.menshanov@gmail.com} ; Anita V. Bannova^a ; Nikolay N. Dygalo^a ; ^b
• 关键词：Glucocorticoids ; Dexamethasone ; Hypoxia ; Anoxia ; Perinatal ; Brain ; Development ; Caspase-3 ; Cortex ; Brainstem
• 刊名：Hormones and Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：122-128
• 全文大小：972 K
• 卷排序：87

文摘

Dexamethasone delays development of the negative geotaxis reaction in the rat pups. Dexamethasone decreases locomotor activity of the rat pups in the novel environment. Mild anoxia attenuates early neurobehavioral alterations induced by dexamethasone. Dexamethasone but not anoxia upregulates active caspase-3 in the cortex and brainstem. Dexamethasone-induced upregulation of active caspase-3 is ameliorated by anoxia.