Based on a meta-analysis of the co-occurrence of bipolar spectrum disorders and somatic symptoms, somatic symptoms are highly prevalent amongst persons with bipolar spectrum disorders (47.8%).

Persons with bipolar spectrum disorders experience somatic symptoms at a rate nearly double that of controls (OR 1.82, 95% CI 1.14–2.92); a rate similar to those with unipolar depression (OR 0.99, 95% CI 0.68–1.44).

Significant heterogeneity exists amongst studies of somatic symptoms in bipolar spectrum disorders.