Design, synthesis and biological evaluation of six dinuclear platinum(II) complexes

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• 作者：Congtao Yu^a ; Chuanzhu Gao^a ; ^{gczasd@163.com} ; Linkui Bai^a ; Qinghua Liu^a ; Zhuxin Zhang^a ; Yingjie Zhang^c ; ^d ; Bo Yang^a ; Chunli Li^a ; ^b ; Peng Dong^c ; ^d ; Xiaojun Sun^a ; ^b ; Yunxu Qian^a
• 关键词：Dinuclear platinum(II) complexes ; Cytotoxicity ; Anticancer ; DNA insertion group
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：27
• 期：4
• 页码：963-966
• 全文大小：456 K
• 卷排序：27

文摘

Six dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1′R,2R,2′R)-N1,N1′-(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, have been designed, synthesized and characterized. In vitro cytotoxicity evaluation of these metal complexes against human A549, HCT-116, MCF-7 and HepG-2 cell lines have been carried out. All compounds showed antitumor activity to HepG-2, HCT-116 and A549. Particularly, compounds A1 and A2 exhibited significant better activity than other four compounds and A2 even showed comparable cytotoxicity to cisplatin against HepG-2 cell line.