Synthesis and biological evaluation of novel dinuclear platinum(II) complexes derived from a novel chiral ligand

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• 作者：Zhuxin Zhang^a ; Chunli Li^a ; ^b ; Xiaojun Sun^a ; ^b ; Chuanzhu Gao^a ; ^{gczasd@163.com} ; Congtao Yu^a ; Qinghua Liu^a ; Linkui Bai^a ; Yunxu Qian^a ; Bo Yang^a ; Peng Dong^c ; ^d ; Yingjie Zhang^c ; ^d
• 关键词：Dinuclear platinum(II) complexes ; (1R ; 1&prime ; R ; 2R ; 2&prime ; R)-N1 ; N1&prime ; -(13-phenylenebis(methylene))dicyclohexane-1 ; 2-Diamine ; Tetradentate ligand ; Antitumor activity
• 刊名：Inorganica Chimica Acta
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：455
• 期：part_P1
• 页码：166-172
• 全文大小：653 K
• 卷排序：455

文摘

Six novel dinuclear platinum complexes with a now chiral tetradentate ligand which own two important pharmacophores (DACH) of oxaliplatin and a DNA insertion group (benzene ring) were degained, synthesized and spectrally characterized. The complex with the most potent antitumor activity, A2, showed better cytotoxicity than carboplatin against HepG-2 and A549 cell lines and also presented a certain activity against HCT-116 which are insensitive to carboplatin.