Chronic exposure to K<sub>ATP</sub> channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

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Chronic exposure to K_ATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

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作者：Elizabeth Haythorne ^{e.haythorne@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; D. Lee Hamilton ^{d.l.hamilton@stir.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; John A. Findlay ^{J.A.Findlay@soton.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Craig Beall ^{C.Beall@exeter.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Rory J. McCrimmon ^{r.mccrimmon@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Michael L.J. Ashford ; ^{m.l.j.ashford@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：NN414 ; Diazoxide ; KATP ; Glucose sensing ; Hypoglycemia ; Type 1 diabetes
刊名：Neuropharmacology
出版年：2016
出版时间：December 2016
年：2016
卷：111
期：Complete
页码：212-222
全文大小：3014 K

文摘

•: Chronic exposure to NN414 blunts hypoglycaemic responses in GT1-7 neurons.
•: NN414 does not cause adaptations in glucose metabolism.
•: The availability of K_ATP to open is greatly diminished by NN414.
•: Preventing NN414 binding or conformation change to K_ATP rescues channel activity.

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