Interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein. Spectroscopic and molecular docking approach

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• 作者：Mohammad Rehan Ajmal^a ; Saima Nusrat^a ; Parvez Alam^a ; Nida Zaidi^a ; Mohsin Vahid Khan^a ; Masihuz Zaman^a ; Yasser E. Shahein^b ; Mohamed H. Mahmoud^c ; ^d ; Gamal Badr^e ; Rizwan Hasan Khan^a ; ^{rizwanhkhan1@gmail.com} ; ^{rizwanhkhan1@yahoo.com}
• 关键词：Human serum α-1 acid glycoprotein ; Human serum albumin ; Fluorescence quenching ; Circular dichroism ; Molecular docking ; Anticancer ; Clofarabine
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：106-115
• 全文大小：3439 K
• 卷排序：135

文摘

Clofarabine caused fluorescence quenching of both HSA and AAG by static mode. There is stronger interaction of clofarabine with AAG as compared to HSA. Binding of clofarabine with HSA and AAG induced ordered structures in both proteins and leads to molecular compaction.