Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells

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• 作者：Hong-bo Huan^a ; Xu-dong Wen^a ; Xue-jiao Chen^b ; Lin Wu^a ; Li-li Wu^a ; Liang Zhang^a ; Da-peng Yang^a ; Xia Zhang^b ; Ping Bie^a ; Cheng Qian^b ; Feng Xia^a ; ^{txzzxf@163.com}
• 关键词：HCC ; hepatocellular carcinoma ; SNS ; sympathetic nervous system ; KCs ; Kupffer cells ; TH ; tyrosine hydroxylase ; AR ; adrenergic receptor ; DEN ; diethylnitrosamine ; 6-OHDA ; 6-hydroxydopamine ; GdCl3 ; gadolinium (III) chloride ; IL-1α ; interleukin-1 alpha ; IL-1β ; interleukin-1 beta ; IL-6 ; interleukin-6 ; IL-8 ; interleukin-8 ; IL-10 ; interleukin-10 ; IL-22 ; interleukin-22 ; TNF-α ; tumor necrosis factor alpha ; IFN-γ ; interferon gamma ; TGF-β ; transforming growth factor beta ; MCP-1 ; monocyte chemotactic protein
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：118-134
• 全文大小：5599 K
• 卷排序：59

文摘

The sympathetic nervous system (SNS) infiltrates the liver and promotes hepatocarcinogenesis. A high density of sympathetic nerve fibers is associated with poor prognosis of hepatocellular carcinoma (HCC) patients. The SNS promotes the activation of Kupffer cells (KCs) via α1-adrenergic receptors in hepatocarcinogenesis. The SNS promotes hepatocarcinogenesis by modulating the activity of KCs and liver inflammation.