Hippocalcin Promotes Neuronal Differentiation and Inhibits Astrocytic Differentiation in Neural Stem Cells

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• 作者：Shin-Young Park¹ ; Sung Nyo Yoon¹ ; Min-Jeong Kang¹ ; YunYoung Lee¹ ; Sung Jun Jung² ; Joong-Soo Han¹ ; ^{jshan@hanyang.ac.kr}
• 关键词：hippocalcin (HPCA) ; neural stem cells ; neurogenesis ; gliogenesis ; phospholipase D1 (PLD1) ; signal transducers and activator of transcription 3 (STAT3) ; phosphoinositide-dependent protein kinase-1 (PDK1) ; SH2-domain-containing tyrosine phosphatase-1 (SHP-1)
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：95-111
• 全文大小：6091 K
• 卷排序：8

文摘

Hippocalcin is required for neuronal differentiation in neural stem cells PKCα/PLD1 activation is required for hippocalcin-mediated neuronal differentiation Blocking of STAT3(Y705) activity by hippocalcin decreases astrocytic differentiation Hippocalcin promotes neurogenesis by inhibiting gliogenesis in neural stem cells