A state-of-the-art FE head model enhanced with DTI data (fractional anisotropy and fiber orientation) and new brain material law is utilized to develop a model based brain injury criterion.

A total of 109 real world head trauma cases are simulated using the advanced head model.

Different intra-cerebral parameters (Von Mises stress, first principal stress, first principal strain, Von Mises equivalent strain, axonal strain, axonal strain rate, CSDM (0.1), CSDM (0.15) and CSDM (0.25)) are extracted to develop a model based criterion.

In-depth Statistical analysis was conducted over different intra-cerebral parameters to find the best suitable parameters to predict diffuse axonal injury (DAI).

Axonal strain provides the best statistical correlation among the other intracerebral parameters and the 50% risk of DAI has been established at 15% of axonal strain.