A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance

详细信息    查看全文

• 作者：Davood Nematollahi^a ; ^{nemat@basu.ac.ir" class="auth_mail} ; Saied Saeed Hosseiny Davarani^b ; Pari Mirahmadpour^c ; Fahimeh Varmaghani^a
• 关键词：2 ; 3-Dihydrophthalazine-1 ; 4-dione ; Cyclic voltammetry ; Electrochemical synthesis ; Sulfonamide ; Arylsulfinic acid
• 刊名：Chinese Chemical Letters
• 出版年：April, 2014
• 年：2014
• 卷：25
• 期：4
• 页码：593-595
• 全文大小：450 K

文摘

The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2,3-dihydrophthalazine-1,4-dione (1) in the presence of arylsulfinic acids (2a and 2b) as nucleophiles. The results show that, the electrogenerated phthalazine-1,4-dione (1ox) participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.