Dual antiplasmodial activity of vitamin D3 and its analog, 22-oxacalcitriol, by direct and indirect mechanisms

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• 作者：Kiichi Yamamoto^a ; ^c ; ^{kyama-q3.3@mopera.net} ; Moritoshi Iwagami^b ; Takenori Seki^a ; Shigeyuki Kano^b ; Nobuo Ota^a ; Manabu Ato^c
• 关键词：VD3 ; vitamin D3 ; (1α ; 25-dihydroxyvitamin D3) ; VD ; vitamin D ; VDR ; vitamin D receptor ; KO ; knock out ; ZA ; zoledronic acid ; IFN-γ ; interferon gamma ; 22-OCT ; 22-oxacalcitriol ; PcAS ; Plasmodium chabaudi AS ; Pf ; Plasmodium falciparum ; PRBCs ; parasitized red blood cells
• 刊名：Parasitology International
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：66
• 期：2
• 页码：89-99
• 全文大小：1912 K
• 卷排序：66

文摘

Extensive inhibition of parasitemia by VD3 in acute phase Delayed parasitemia peak in chronic phase is independent on mortality. Hypercalcemia links to anti-plasmodial activity. Anti-plasmodial activity of VD3 in B6 or B10 mice is IFN-γ independent mechanism. In vitro anti-plasmodial activity was confirmed with VDR-KO mice in vivo.