New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G-Quadruplex DNA binding selectivity and application in live cell imaging

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New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G-Quadruplex DNA binding selectivity and application in live cell imaging

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作者：Yu-Jing Lu^a ; ^{luyj@gdut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Dong-Ping Hu^a ; Kun Zhang^a ; Wing-Leung Wong^b ; ^{wingleung@ied.edu.hk" class="auth_mail" title="E-mail the corresponding author} ; Cheuk-Fai Chow^b
关键词：G-Quadruplexes DNA ; Telo21 ; Distyrylpyridinium dye ; Fluorescence probe ; Cell imaging
刊名：Biosensors and Bioelectronics
出版年：2016
出版时间：15 July 2016
年：2016
卷：81
期：Complete
页码：373-381
全文大小：1292 K

文摘

•: Understanding the effects of symmetry (C1, C2, C3-symmetric) and styrene-like side groups on G-Quadruplexes DNA selectivity.
•: Sensitive and selective fluorescent dye for G-Quadruplexes DNA and imaging in live cells.
•: High equilibrium binding constant (2.17×105 M⁻¹) and low limit of detection (33 nM) for telo21 DNA in bioassays.

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