Human Dental Pulp Stem Cells Suppress Alloantigen-induced Immunity by Stimulating T Cells to Release Transforming Growth Factor Beta

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• 作者：Kyu Hwan Kwack ; DVM^&lowast ; ; Jung Min Lee ; DMD ; PhD^&dagger ; ; Sang Hyuk Park ; DMD ; PhD^&dagger ; ; ^{shpark94@khu.ac.kr} ; Hyeon Woo Lee ; PhD^&lowast ; ; ^{hyeonwoo@khu.ac.kr}
• 关键词：Allogeneic transplantation ; human dental pulp stem cells ; immunosuppression ; pulp regeneration ; transforming growth factor beta
• 刊名：Journal of Endodontics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：43
• 期：1
• 页码：100-108
• 全文大小：2564 K
• 卷排序：43

文摘

Total cell preparations enzymatically purified from dental pulp possess the generic mesenchymal stem cell phenotype. Human dental pulp stem cells have an inhibitory effect on alloantigen-evoked peripheral blood mononuclear cell proliferation and immunoglobulin (Ig) M and IgG production. hDPSCs inhibit allogeneic adaptive hyperimmune responses by their release of transforming growth factor beta as a result of allogeneic stimulation of T lymphocytes and the production of interferon gamma.